Changes in blood coagulation following coronary thrombosis measured by the heparin retarded clotting test (Waugh and Ruddick test).

نویسندگان

  • J H OGURA
  • N R FETTER
چکیده

Recently many authors have studied the phenomenon of accelerated coagulability of the blood in a variety of conditions. It is now well known that numerous factors may play a role in increasing the coagulability of the blood. This tendency toward an increasing coagulability of the blood will be referred to as "acceleration" throughout this paper. Among factors which may accelerate the coagulation of blood should be mentioned stasis of blood, trauma to vessel walls, dehydration, anemia, and the release of excessive quantities of thromboplastin in the blood such as occur after trauma, surgery, infection, or childbirth. Each of these factors may act independently or in conjunction with the others. De Takats (1) demonstrated a change in the clotting mechanism in a variety of thrombotic states such as venous thrombosis, cerebral thrombosis, arterial embolus and coronary thrombosis. Brambel et al. (2) demonstrated a tendency toward acceleration of coagulation using Quick's prothrombin test with 12.5 per cent diluted plasma in crush injuries associated with gangrene, diabetic and arteriosclerotic gangrene and frost bite. Shapiro (3, 4) has also demonstrated a tendency to accelerated coagulability of the blood using diluted plasma, and thought it significant in thromboembolization. He found in 5 cases of embolization a lowered prothrombin time. Hirschboeck (5) found in 9 out of 10 cases of pulmonary embolism a decrease in clot retraction time. Shafiroff et al. (6) found, using the Lee-White technique, that blood from a limb affected with thrombosis or phlebitis, as compared with blood taken from a normal limb in the same subject, showed accelerated coagulation.

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عنوان ژورنال:
  • The Journal of clinical investigation

دوره 25 4  شماره 

صفحات  -

تاریخ انتشار 1945